"These Dots like many of the Twinlabs sublingual products, deliver the formula through the lingual muscosa rather than the stomach -- a much faster less complicated pathway to the circulatory system and brain. This delivery also means your liver does not deactivate some of it before your body gets to use what it needs. (That's why taking hormones through the skin rather than by mouth is more effective and less burden on the liver.) These DOTS seems to work gently and because you melt them slowly in your mouth, under your tongue, the effects feel more natural. I find it easy to take at bedtime, effective and easy to titrate (that is regulate the dose by how many sublinguals you use)."