100% Natural. Hoodia is a natural appetite suppressant derived from the Hoodia gordonii cactus plant and has no known side effects. It has been reported to reduce the appetite by 30%. The Science Behind The Product. Natural 100% Hoodia. Appetite Suppressant 200mg Capsules. The most powerful appetite suppressant ever: 100% natural with no known side effects. For generations the San people of South Africa have been using the hoodia cactus to alleviate intense hunger pains on long hunting trips for days at a time without side effects. Scientific research suggests Hoodia suppresses the appetite by fooling the brain into believing you are full and thereby stops you from thinking about food. Hoodia contains an active ingredient which mimics the effects that glucose has on the hypothalamus of the brain suppressing our appetite. Research has shown that the plant can reduce appetites 30%-40% allowing the user to eat less without feeling hungry.