Production of DHEA Decreases with Age. Supplementation has been Shown Support Overall Health. DHEA (dehydroepiandrosterone) is produced in the adrenal glands from pregnenolone and eventually converted into testosterone estrone and estradiol. As we age decreasing levels of DHEA could be pivotal to the onset of decreased health. DHEA supplementation has shown an ability to return levels to those experienced in younger years and support overall health*.