Cocarboxylase. In order for vitamins to be utilized by the body they must first be converted into their active coenzyme forms. Sublingual Coenzymated B-1 goes directly into your bloodstream in its active form ready to go to work immediately. This avoids the loss that may occur not only during digestion but during the liver’s conversion process as well. Thiamin diphosphate (TDP) also called thiamin pyrophosphate (TPP) or cocarboxylase is the active coenzyme form of vitamin B-1.